key Try Dr. Aronoff's BASIC ESRD PHARMACOKINETICS . This quiz deals with issues of dialyzability of drugs, how to give drugs to ESRD patients that are removed by dialysis, with examples of severe side effects from two drugs that can manifest in ESRD patients.
Note: The feedback section of this quiz works only with Internet Explorer, and not with Firefox.

Aronoff

Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer?
How does epoetin alfa work? What is CERA and how is it different? What are the half-lives of various ESAs and how may this impact therapy and cost? What is Hematide and how does it work? What are prolyl hydroxylase inhibitors and how do they affect anemia? What are initial results with FG-2216? How can ESA dosing be individualized using a neural net approach? (RPA 2006 Satellite Symposium) (more...)

Updated: November 19, 2008 (N19)
N19 Did you know that your prescribing history is for sale? Fed appeals court supports NH law banning the practice.
N19 FDA advisory panel greenlights anti-MRSA antibiotic telavancin, but not approved by the FDA yet.
N18 New microRNA compound protects mice against heart failure.
N18 Five days of cipro cause pervasive and persistent changes in gut microflora abundance.
N14 Renal Week: Relative vitamin K2 deficiency linked to vascular calcification in ESRD
N09 Rosuvastatin given to patients with normal cholesterol levels but high CRPs markedly lowers CV risk.
N06 Ghrelin-like drug increases muscle mass by 20% in the elderly.
N04 Strange, complex pharmacokinetics of methotrexate in RBCs have implications for clinical treatment.
O29 Animal studies suggest potential benefits of drug holiday for patients taking sulfonylureas.
O28 Topical treament for HSV cold sores achieves same results as oral systemic therapy.
O28 Plavix (clopidogrel) may be inactivated by some calcium channel blockers.
O27 Risks of irregular heartbeat and atrial fibrillation increased with fosamax and other bisphosphonates.
O27 Pentoxifylline lowers proteinuria alone or in addition to an ACE inhibitor.
O23 Hydrogen sulfide may be a key regulator of blood pressure.
O23 European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
Industry Advances Emphasis
archive
Searching for a Novel Erythropoietic Treatment: What Does the Future Have to Offer? (Aronoff) RPA Satellite Symposium 2006
Literature Review: Non-Potassium Fluid-Electrolyte and Acid-Base Disorders (Palmer) ASN Renal Week 2005
The Pathway to Approval of Novel Agents for Renal Diseases (Greene, Throckmorton, Lewis) ASN Renal Week 2005 (audiofiles)
Contrast Induced Nephropathy (CIN): Clinical Significance and Prevention (Palevsky, Tumlin) ASN Renal Week 2005 (audiofiles)
Metals, the Environment, and Miscellaneous Toxins (Batuman, Nortier, Ritz, DeBroe, Lewis, Wolfe) ASN Renal Week 2005 (audiofiles)
Prescribing for Patients with CKD Including Dialysis (Swan, Bennett, DeBroe, D'Haese) ASN Renal Week 2005 (audiofiles)
General Aspects of Nephrotoxicity and Analgesics (Perazella, Markowitz, Clark, DeBroe, Elseviers, Henrich) ASN Renal Week 2005 (audiofiles)
Specific Nephrotoxins (Molitoris, Berns, Palevsky, Shihab, Launay-Vacher, Isnard-Bagnis) ASN Renal Week 2005 (audiofiles)
Statins as Anti-Inflammatory Drugs (Wheeler) RRI 2005 (audiofiles)
New Phosphate Binders (Bargman) ADC 2005 (audiofiles)
Herbs and Heavy Metals: A Recipe for Kidney Failure (Kupin) ASN Board Review 2004

Balkan Nephropathy: Evolution of Our Knowledge (Bamias and Boletis) Am J Kidney Dis (Sep 2008)
Pharmacogenetics of immunosuppressants: progress, pitfalls and promises (Cattaneo D et al) Am J Transplant - Jul - 08
Sensing tension: epithelial sodium channel/acid-sensing ion channel proteins in cardiovascular homeostasis Hypertens (2008)
Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD Am J Kidney Dis (May 2008)
The Janus faces of allopurinol -- allopurinol hypersensitivity syndrome Am J Med (Mar 2008)
Beta-blockade in chronic dialysis patients Semin Dial (Feb 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
Drug dosing considerations in alternative hemodialysis (Decker et al) Adv Chronic Kidney Dis (Jul 2007)
Gadolinium use in patients with kidney disease: A cause for concern Semin Dial 05-07
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
Aldosterone and Cardiovascular Disease. Smoke and Fire (Calhoun). Circulation 12-06
Lessons for Medicare Part D in the hemodialysis community (Nayeem, Chertow) BMC Nephrology 07-06
ESRD PHARMACOKINETICS
Drug Dosing in Renal Failure
(link now works)
HDCN Topic Pages
Interstitial Nephritis
Adverse drug effects
OTHER LINKS
Australian Prescriber
Drug Facts and Comparisons
GSM Clin Pharm
Manufacturer Directory
MedPharm Pharmacology Links
Nephrology Pharm Assoc
Pharmacy Times Links
PowerPak Pharm CE
Renal Pharmacist Network
U.S. Pharmacopoeia

Dr. George Aronoff, M.D.
Professor of Medicine and Pharmacology, University of Louisville School of Medicine, Louisville, KY.