Lewis  

Emerging New Agents in Diabetic Kidney Disease
(Julia Lewis, MD. ASN Renal Week 2005). There are at least five new approaches beyond ACE inibitors to diabetic nephropathy: Aldosterone blockers, ruboxistaurin, prifenidone, COX-2 inhibition, and sulodexide. What is the rationale for each of these interventions and what do the early pilot studies show?
(more...)



Williams  

Coronary Angioplasty and Stenting: Indications and Results
(Mark Williams, MD. ASN Renal Week 2005). In diabetics mortality with CAD is increased and classically they do worse with percutaneous interventions due to restenosis rathen than with bypass surgery. Is this also true for diabetic patients with CKD? To what extent has the picture changed with the use of drug-eluting stents? What are the anti-thrombotic strategies that can be used in such patients after stenting and how do these influence outcomes?
(more...)



McGill

The Role of Glycemic Control and How Best to Achieve it
(ASN Renal Week Clinical Nephrology Conference November, 2005, Philadelphia, PA)
To what extent does HbA1c predict adverse events in diabetics? In non-diabetics? How low must one go to avoid the increased CV risk? Is <7.0% low enough? What did follow-up from the DCCT/EDIC trials show? What is the benefit of multiple risk factor reduction (Steno-2 Trial)? What is the modern approach to glucose control, including use of metformin (in non-CKD), alpha-glucosidase inhibitors, incretins, secretagogues, and thiazolidinediones? What are practical points regarding use of PPAR-gamma agonists, exenatide? What are the benefits of the thiazolidinediones in terms of lipids, prevention of restenosis, and reduction of albuminuria? (more...)

Updated: November 27, 2008 (N27)
N27 Mechanism of how the brain senses fatty foods identified.
N26 Vitamin K deficiency linked to insulin resistance in older men
N18 Anticancer drugs sunitinib and imatinib cause remission of type 1 diabetes in mice.
N09 Rosuvastatin given to patients with normal cholesterol levels but high CRPs markedly lowers CV risk.
N07 Covidien recalls miscalibrated insulin syringes (overdose risk!) sold at Wal-Mart and Sam's Club.
N04 Intraocular anti-VEGF drugs to treat retinal proliferative disoders may have a dark side.
N04 New SIRT1 activating drug may protect against diet-induced obesity.
N04 Incidence of proteinuria reduced in those diabeics who eat fish at least once a week.
O30 CDC issues new count of diabetes in the U.S. by state. Overall rate nearly doubles.
O30 Alpha-1-antitrypsin treatment improves success rate of pancreatic islet cell transplants.
O29 Animal studies suggest potential benefits of drug holiday for patients taking sulfonylureas.
O27 Costs of treating diabetes has nearly doubled in past 7 years.
O27 Pentoxifylline lowers proteinuria alone or in addition to an ACE inhibitor.
O23 European watchdog agency suggests not using diet drug rimonabant due to depression side effects.
O23 New diet drug tesofensine appears to be remarkably effective.
General Advances Emphasis
archive
Emerging New Agents in Diabetic Kidney Disease (Lewis) ASN 2005 Renal Week
Coronary Angioplasty and Stenting: Indications and Results (Williams) ASN 2005 Renal Week
Disease Management Actually Works in Dialysis Patients (Sands) RRI 2006, Part 2 (handouts)
Optimizing the Total Care of the Diabetic Patient with Kidney Disease - Lipids (Molitch) ASN Renal Week 2005
Optimizing the Total Care of the Diabetic with Kidney Disease (McGill, Kaplan, Molitch, Williams) ASN Renal Week 2005 (audiofiles)
Obesity and the Kidney (Lord, Scherer, Fliser) ASN Renal Week 2005 (audiofiles)
Novel Pathways for Prevention of Diabetes and Obesity-Related Renal and Vascular Disease (Cooper, Danesh) ASN Renal Week 2005 (audiofiles)
Newer Approaches to Diabetic Kidney Disease (Hollenberg, Lewis, Pavlakis) ASN Renal Week 2005 (audiofiles)
Diabetes and Dialysis (Oreopoulos, Friedman, Dasgupta, Kopple) ADC 2005 (audiofiles)
The Metabolic Syndrome and Kidney Disease: An Important Complication of Systemic Vascular Disease (Tuttle) ASN 2004
New Insights in the Pathogenesis of Uric Acid Nephrolithiasis (Sakhaee) ASN 2004

Population-based prevention of obesity: the need for comprehensive promotion of healthful eating, physical activity, and energy balance: A Scientific Statement From American Heart Association (Kumanyika SK et al) Circulation Jul 08
Screening for Type 2 Diabetes Mellitus in Adults: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (Jun 2008)
Large artery stiffening with weight gain in humans: role of visceral fat accumulation Hypertens (Jun 2008)
Debate: Weight loss and blood pressure control (Pro) vs. Dietary therapy for obesity: an emperor with no clothes (Con) Hypertens (Jun 2008)
Screening for gestational diabetes mellitus: U.S. Preventive Services Task Force Recommendation Statement Ann Intern Med (May 2008)
Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care Diabet Care (May 2008)
Lipoprotein management in patients with cardiometabolic risk: Consensus statement from the American Diabetes Association and the American College of Cardiology Foundation Diabet Care (Apr 2008)
Hyperglycemia and acute coronary syndrome: A Scientific Statement From the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation (Mar 2008)
Management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: Update regarding thiazolidinediones: a consensus statement from the ADA/EASD Diabet Care (Jan 2008)
Adiponectin, cardiovascular function, and hypertension Hypertens (Jan 2008)
Rosiglitazone decreases albuminuria in type 2 diabetic patients (Miyazaki et al) Kidney Int (Dec 2007)
Long term pharmacotherapy for obesity and overweight: updated meta-analysis (Rucker et al) Brit Med J (Dec 2007)
2007 Chronic angina focused update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina: A Report of the ACC/AHA Task Force (Fraker Jr et al) Diabet Care (Dec 2007)
Obesity paradox in patients with hypertension and coronary artery disease (Lavie et al) Am J Med (Oct 2007)
Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review (Eurich et al) Brit Med J (Sep 2007)
Impact of glucose levels on advanced glycation end products in hemodialysis (Godfrey) Hemodial Int (Jul 2007)
Intensive versus moderate blood-pressure control in normotensive patients with type 2 diabetes (Briggs J) NCPN Jun 07
Hypomagnesemia in patients with type 2 diabetes (Pham et al) CJASN (03-2007)
Hypomagnesemia in patients with type 2 diabetes CJASN 03-07
KDOQI Clinical Practice Guidelines and CPRs (2006 update) for Treatment of Diabetes and CKD AJKD (Feb 07)
(2006 Pharma )Year in Review (Michele B. Kaufman, PharmD, RPh) Dial-Transplant 12-06
ACE2: A new target for prevention of diabetic nephropathy? (Ingelfinger JR, commenting on an article by Batlle's group) JASN 11-06
Advanced glycation end products and nephrotoxicity of high-protein diets (Uribarri, Tuttle) CJASN 11-06
Angiotensin-converting enzyme-2 (ACE-2) - a new player in the genesis of glomerular injury? (Comment by Ritz on paper by Oudit et al) JASN 10-06
Management of dyslipidemias in patients with diabetes and chronic kidney disease (Molitch). CJASN 09-06
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